The ask seemed straight forward.
"In human medicine, most habitancy would agree that a someone gets sick with a cold or with the flu when their immune system is suppressed. Has anyone thought about what is suppressing the immune system of the habitancy and chickens in Vietnam, production them more susceptible to deadly effects of H5N1? Has anyone investigated what is suppressing the immune system of migratory birds?" The ask was posed to Dr. Alex Thiermann, President of the Oie, the World assosication for Animal health at the First Bird Flu Summit held in Washington, Dc, February 27-28, 2006. His response, "No one is seeing at this, in fact, no one has even opinion about it" was echoed by the reporters and scientists during the ensuing coffee break.
News From Cambodia
An investigation into the immunosuppressive effects of environmental chemicals--with a single focus on dioxin--may shed light into the seemingly scattered and disconnected outbreaks of bird flu colse to globe. The association between dioxin and influenza may even interpret the increased whole of deaths in China, Vietnam, and in particular, Indonesia.
Dioxin: The most toxic chemical on earth
Dioxin is a general term that describes a involved house of more than 400 chemicals. An unintentional waste product, dioxin is formed during commercial processes which incorporate chlorine with an organic substance, such as wood, pulp or paper, in the nearnessy of heat. Yield facilities that establish pesticides smelt copper and bleach paper all issue of dioxins as by-products. Additionally, dioxin can enter the environment through the incineration of plastics, particularly those that burn municipal and curative waste.
A very persistent chemical, dioxin can take more than 15 years to degrade to half its original concentration. If released into the local water supplies--for example, ponds and rivers--it can regain in fish. If not immediately absorbed by aquatic life, the remaining dioxin is rapidly deposited into the sediment. It will remain there, virtually forever, unless it moves up the food chain through grasses and frogs, becoming particularly toxic to humans and waterfowl.
Dioxin has been shown to disrupt the immune system at exposures as low as 1.0 ppt. This is the equivalent of a single drop of liquid placed in the town car a ten-kilometer (6.2 miles) long cargo train.(1) Because chemicals are usually a aggregate of toxic and non-toxic compounds, a score for each chemical is advanced called its Toxic Equivalency (Teq). The Teq of any chemical is established by comparing it to Tcdd, the most toxic form dioxin in the world.
Dioxin combined with influenza viruses: Serious consequences
A specific link exists between dioxin exposure and the corollary of influenza viruses on the immune system, a association that has been studied using laboratory mice.
Research has clearly demonstrated that two types of white blood cells, Natural Killer (Nk) and Cd8+ cells, are exquisitely sensitive to very small concentrations of Tcdd. Studies have shown that if mice are subjected to 100-1,000 ppt of Tcdd prior to being exposed to coarse influenza A viruses, the whole of mice that died was significantly higher than the whole of control mice that were not pre-exposed to this dioxin.(2) In someone else study, when mice were subjected to a mere 10 ppt of Tcdd one week before they were exposed to influenza A viruses, the mortality rate among the mice doubled. Researchers noted that this was the "smallest toxic dose of dioxin ever demonstrated" to inhibit the capability of the immune system to ward off the flu.(3)
In a third study, fluid extracted directly from the lungs of deceased mice demonstrated that the increased mortality seen in Tcdd-exposed mice was due to the intense inflammatory operation of dioxin. Death was not due to viral infection alone.(4) In other words, the aggregate of influenza viruses and dioxin caused so much inflammation in the lungs--due to a huge cytokine storm--that general lung tissue was destroyed, foremost to death of most of the mice.
Dioxin in Vietnam
The volume of herbicides sprayed during the U.S. Friction in Vietnam between 1961 and 1971 has been estimated that more than 19 million liters. The highest concentrations were deposited over the Mekong Delta in what is now southern Vietnam. The packaging with dioxin were known as Agent Orange, identified by orange striped barrels. More than 30 years later, this persistent chemical remains in the soil and food of local residents, persisting to cause serious health problems.
Absent ongoing aerial spraying, dioxin's original route for entering the body is through food grown on toxic soils. Canadian researchers found that dioxin levels in soil samples throughout distinct regions of southern Vietnam to be as high as 898 ppt. The most greatest levels of contamination-in the area of Bien Hung Lake-were measured to be greater than 1.1 million ppt.(5)
In 2002, levels of dioxin were measured in 16 distinct food samples were collected from local markets colse to the Bien Hung Lake in southern Vietnam. The preliminary results were startling. Three of the specimens contained dioxin levels that were so extraordinarily high they were sent to a second, independent laboratory for additional analysis. The second lab confirmed the disturbing results. In the final report, chemical contaminants and large concentrations dioxin, up to 536 ppt, were detected in all 16 food samples. To put these elevated levels in perspective, the usual dioxin level found in food is less than 0.1 ppt.(6)
Dioxin, influenza and humans: a connection?
In May 2006, Indonesia reported a knot of human bird flu cases that involved eight house members, seven of whom died. All but one someone in the house appeared to have contracted the virus from someone else house member. This became the first reported incidence of H5N1 spreading from one someone to another, and then another. Alarmed officials feared that the bird flu virus had acquired characteristics that would soon allow easy duct from human-to-human.
The members of the deceased house lived in a small village in Karo district placed in the Indonesian province of North Sumatra. The Karo highland borders on Lake Toba, the world's largest volcanic lake. The largest lake in Southeast Asia, Toba has been deteriorating since 1998, defenseless against Indorayon, a paper, pulp and rayon builder owned by multinational fellowships and funded by the World Bank. Untill it was shut down, Indorayon was the largest polluter of Lake Toba in the past decade, dumping tons of chlorine and dioxin into the waters.
Interestingly, hundreds, maybe thousands, of individuals with H5N1 influenza have not been sick adequate to wish curative care, as confirmed by Dick Thompson, spokesperson for the Who in March, 2005.(7) However, between 2003 and April, 11, 2007, there have been 291 cases and 171 deaths, with 61% of the deaths in Vietnam and Indonesia. An investigation, maybe along with a fat biopsy, should be undertaken to rule if those who died had significantly higher concentrations of dioxin in their body than those who have been exposed to H5N1 and remained well or fully recovered.
What can be done?
A global pandemic is brewing, but not because a virus may "jump species" and rapidly circumnavigate the globe, wiping out everyone in its wake. It appears that only those most at risk will be affected. But critically foremost information is missing: What is each person's personel level of risk? Beyond spending billions on global bureaucratic preparedness, true arresting is in order through developing tests and detoxification methods for humans.
Instead of funding the improvement a vaccine that as a marginal chance of being effective, billions of dollars would be best spent funding international environmental clean up programs. Legislative initiatives that put compulsion teeth into international treaties that are already on the books may be the best way of aborting disaster.
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(1) Quynh, Hoang Trong, Md, et al. "Long-term consequences of Vietnam War," Nordic News Network, article to the Environmental seminar on Cambodia, Laos and Vietnam.
(2) Burleson, G. R., et al. "Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (Tcdd) on influenza virus host resistance in mice," Toxicological Sciences, 29 (1996): 40-47
(3) Burleson, G. R., et al. "Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (Tcdd) on influenza virus host resistance in mice," Toxicological Sciences, 29 (1996): 40-47.
(4) Luebke, R. W, et al. "Mortality in dioxin-exposed mice infected with influenza: mitochondrial toxicity (Reye's-like syndrome) versus enhanced inflammation as the mode of action," Toxicological Sciences 69 (2002): 109-116.
(5) Schecter, A., Quynh, H. T., Pavuk, M., Papke, O., Malisch, R., Constable, J. D. "Food as a source of dioxin exposure in the residents of Bien Hoa City, Vietnam," Journal of Occupational and Environmental medicine 45 (2003): 781-788. Pmid: 12915779.
(6) Schecter A., et al. "Food as a source of dioxin exposure in the residents of Bien Hoa City, Vietnam," Journal of Occupational and Environmental medicine 45 (2003): 781-788. Pmid: 12915779.
(7) 23 Roos, Robert. "Relatives of avian flu patients have asymptomatic cases," Cidrap News, 9 March 2005.
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